Endocrine Abstracts

Introduction: The discovery of incidental thyroid carcinomas (ITC) in patients undergoing surgery for a benign disease range between 3 and 16% of cases. During years, patients with hyperthyroidism were considered protected by TSH suppression (TSH is well known factor that favors the development of thyroid cancer). Thyroid size might be a predictive factor due to the excess of thyroid tissue prone to mutations. The knowledge of determining factors foretelling the presence of un...

Introduction: Most recent ATA thyroid nodule/DTC guidelines recommend thyroidectomy without prophylactic CND for small (T1 or T2), non-invasive, clinically node-negative PTC (cN0). However, some studies have suggested an association between the BRAFV600E mutation and the risk of nodal disease. Moreover, BRAF V600E mutation have recently showed significant association with recurrence in solitary intrathyroidal PTC between 2 and 4 cm (pT2) making suitable a more aggressive treat...

Introduction: Subclinical hypercortisolism (SH), a condition of biochemical cortisol excess without the classical signs or symptoms of overt hypercortisolism, is thought to be present in the 5–30% of patients with incidentally discovered adrenal mass (adrenal incidentalomas). Some evidence suggest that this condition may lead to long-term consequences of cortisol excess, but indication and potential benefits of adrenalectomy in this state are still in doubt. We analyse a ...

Objective: To compare the results of immunohistochemistry (IHC) and DNA sequencing in detection of BRAF V600E mutation in papillary thyroid carcinomas (PTC). BRAF V600E mutation is the most common genetic alteration in papillary thyroid carcinomas and is associated with worse prognosis. Direct sequencing is usually performed, but less expensive immunohistochemistry can be used instead.Methods: Study was performed in 54 consecutive PTCs during 2014–2...

TSH level has been proposed as a thyroid malignancy predictor in nodular thyroid disease. In addition, several clinical studies have reported that higher preoperative serum TSH levels were associated with more advanced stages of differentiated thyroid cancer (DTC) at the time of diagnosis.Methods: We collected retrospectively preoperative serum TSH from patients diagnosed of papillary thyroid cancer (PTC) who had undergone total thyroidectomy during the ...

Higher serum TSH has been recently postulated as a predictor of thyroid malignancy in nodular thyroid disease. In addition, some reports have demonstrated its association with more advanced stages of differentiated thyroid cancer (DTC).Material and methods: We collected retrospectively preoperative serum TSH from patients who underwent total thyroidectomy in the period 2005–2011 in a single tertiary center. We recorded demographic data, nodule numbe...

Current guidelines recommend measurement of rhTSH-stimulated Tg, with neck ultrasound 6–12 months after the initial therapy for DTC (Total thyroidectomy plus 100 mCiI131 ablation of the thyroid bed). Uncertainty persists regarding whether the subsequent follow up should be based on measurement of basal serum Tg or whether rhTSH-stimulated Tg should be performed and at what frequency. The aim of our study was to evaluate the utility of repeated rhTSH-stimulated Tg.<p c...

Increasing incidence of papillary thyroid microcarcinoma (PTMC) is due to accurate histological study of surgical specimens (incidental, INC) or to improved preoperative diagnostic techniques (preoperatively diagnosed, PD). We evaluate the differences between both groups of PTMC from 2000 to 2009.We reviewed data of patients diagnosed of PTMC (<10 mm) during the last decade with complete follow-up since surgery. Demographic data, tumour size, histolo...

Autoimmune polyendocrinopathy syndromes (APS) gather a wide range of diseases. The association of autoimmune thyroid disease (ATD) with other organ specific diseases is frequent. Atrophic body gastritis (ABP) is characterized by the loss of ClH and intrinsic factor (IF) production. Both ATD and ABP are known to be associated since 1960 but there are scarce publications describing its clinical features.We review patients with this association selected fro...

Surgery followed by 131I ablative therapy (IAT) is the usual treatment for patients with differentiated thyroid carcinoma (DTC). Thyroglobulin levels obtained 9–12 months after IAT under TSH stimulation (Tg2) is a very reliable marker for the presence of thyroid tissue. The value of stimulated thyroglobulin previous to ablation (Tg1) is more controversial. The aim of this study was to examine the relationship between Tg1 and Tg2.Material ...